Document Type
Article
Abstract
While preparing novel cysteine derivatives as oxidation catalysts, we needed S-tert-butylcysteine. We also examined acid-promoted tert-butylation of thiols using tert-butanol as reagent and solvent. While cysteine and aminoethanethiol work well using tBuOH in 4M HCl, other thiols fail in the aqueous environment and aerobic conditions. We examined a variety of aliphatic and aromatic thiols in tBuOH with H2SO4 catalysis and found that argon sparging and the use of 1 eq of acid led to good yields in a parallel format.
Publication Date
Spring 5-21-2012
Recommended Citation
Norcross, Rebecca; Stanfield, Jessica; and Fitch, Richard W., "Convenient Parallel Synthesis of Alkyl- and Aryl-S-tert-Butyl Thiothers" (2012). Symposium 2012. 8.
https://scholars.indianastate.edu/symposium/8
Included in
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Comments
Faculty Sponsor: Richard W. Fitch